2 malignancies of DIFFERENT strains in the same location and with the SAME virus involved
#ENTpath #EBV
💫 1st set: Nasopharyngeal Carcinoma (non-keratinizing squamous cell carcinoma type)
H-E, CK5/6 (also p63+ not shown) and EBER-ISH

Widely metastatic Acantholytic SCC showing an almost plasmacytoid and melanoma-like appearance. IHC confirms epithelial/squamous nature! S100, Malan-A, HMB45 and SOX10 are negative. #headandneckpathology #headandneckcancer